Table 4 |
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Lutein and Age Related Macular Degeneration (ARMD), With Dietary Intake Assessed by 6 24 HR's: Standardized Relative Risks (RR*), Statistical Power and Relative Sample Size** (rss) Required for Various Analysis Strategies Under Different Disease Risk Models |
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|
Analysis Strategy |
Disease Risk Model |
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|
(a) Not mediated through marker |
(b) Mediated entirely through marker |
(c) Partially mediated through marker |
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|
|
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|
RDIa (univariate) |
RR Power (rss) |
0.43 0.890 (1.00) |
0.55 0.629 (1.00) |
0.49 0.810 (1.00) |
|
MBLb (univariate) |
RR Power (rss) |
0.47 0.829 (1.20) |
0.32 0.995 (0.25) |
0.38 0.972 (0.54) |
|
Bivariatec |
RR RDI RR MBL Power (rss) |
0.53 0.61 0.904 (0.95) |
0.87 0.33 0.986 (0.30) |
0.67 0.44 0.968 (0.55) |
|
Howed (ranks) |
RR Power (rss) |
0.38 0.959 (0.74) |
0.34 0.985 (0.31) |
0.35 0.974 (0.53) |
|
Principal Componentse |
RR Power (rss) |
0.39 0.952 (0.77) |
0.35 0.984 (0.31) |
0.37 0.977 (0.51) |
|
|
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* Standardized relative risk is defined as the RR between the 90th and 10th percentiles of the distribution. Bold type indicates the most powerful method among the available choices investigated. ** Sample size requirement relative to the univariate RDI analysis. a Regression of ARMD on RDI b Regression of ARMD on MBL c Regression of ARMD on RDI and MBL d Regression of ARMD on combination of RDI and MBL using Howe's method e Regression of ARMD on combination of RDI and MBL using Principal Components |
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Freedman et al. Epidemiologic Perspectives & Innovations 2010 7:2 doi:10.1186/1742-5573-7-2 |
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