EP&I


Open Access Analytic Perspective

Can we use biomarkers in combination with self-reports to strengthen the analysis of nutritional epidemiologic studies?

Laurence S Freedman1*, Victor Kipnis2, Arthur Schatzkin3, NataĊĦa Tasevska4 and Nancy Potischman5

Author Affiliations

1 Biostatistics Unit, Gertner Institute for Epidemiology, Tel Hashomer 52161, Israel

2 Division of Cancer Prevention, National Cancer Institute, 6130 Executive Boulevard, EPN-3131, Bethesda, MD 20892-7354, USA

3 Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS-3040, Bethesda, MD 20892-7232, USA

4 Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS-3040, Bethesda, MD 20892-7232, USA

5 Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, 6130 Executive Boulevard, EPN-4008, Bethesda, MD 20892-7344, USA

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Epidemiologic Perspectives & Innovations 2010, 7:2 doi:10.1186/1742-5573-7-2

Published: 20 January 2010

Additional files

Additional file 1:

Detailed calculations of the parameters for the simulations and further results. Contains (a) data from the papers in the literature on lutein intake, serum lutein and macular degeneration and how they are used to calculate the parameters in the proposed statistical model; (b) data from the papers in the literature on beta-cryptoxantin intake, serum beta-cryptoxanthin and stomach cancer and how they are used to calculate the parameters in the proposed statistical model; and (c) tables presenting results of simulation of the model for beta-cryptoxanthin and stomach cancer.

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